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目的:探讨皖北地区胆红素水平与高血压及血压水平的关系。方法:选取2017年3～9月流行病学调查的皖北某市人民医院体检中心人群1138例为研究对象,根据血压分为高血压组599例(服药368例,未服药231例),血压正常组539例。比较各组总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)水平差异,并对患者相关临床资料进行统计学分析。结果:高血压服药组、高血压未服药组与对照组在年龄、血脂、血糖、体质量指数、TBIL、DBIL和IBIL的水平存在差异(P<0.05)。高血压服药组的TBIL、DBIL、IBIL水平均高于对照人群,尤其在女性人群中,对照组、高血压未服药组和高血压服药组DBIL的水平分别为(2.87±2.79)μmol/L、(3.22±1.59)μmol/L、(3.80±2.26)μmol/L,呈线性增长趋势(P<0.05)。相关分析表明,TBIL、DBIL、IBIL和SBP成弱正相关,IBIL和DBP成弱正相关(均P<0.05)。Logistic回归分析结果显示,TBIL、DBIL、IBIL水平和高血压服药组呈正关联性,且DBIL水平的增加是高血压未服药组的危险因素(P<0.05)。结论:胆红素水平在高血压服药患者血清中浓度升高,且与性别有一定关联。
Abstract：Objective:To investigate the relationship between bilirubin level and blood pressure variation and hypertension in population in northern Anhui province.Methods:1138 subjects undergoing physical examination from March to September of 2017 in a hospital in north Anhui province were included,and allocated to hypertension group(n=599,in whom 368 were in antihypertensive medication,and 231 were left untreated),and normal blood pressure group(n=539,controls).The levels were compared on total bilirubin(TBIL),direct bilirubin(DBIL)and indirect bilirubin(IBIL)among groups,and the related clinical data were statistically analyzed.Results:The difference was significant in age,content of blood lipid and glucose,body mass index,TBIL,DBIL and IBIL levels among antihypertensive medication group,untreated group and control group(P<0.05).Patients administered with antihypertensive drugs had higher levels of TBIL,DBIL and IBIL than those in control group.Stratification analysis showed that DBIL level was in linear increase among the control group,untreated group and antihypertensive medication group in females,the level was(2.87±2.79),(3.22±1.59)and(3.80±2.26)μmol/L,respectively(P<0.05).The results by correlation analysis showed that TBIL,DBIL and IBIL as well as IBIL were weakly correlated with SBP and DBP(allP<0.05).Logistic regression analysis indicated that levels of TBIL,DBIL and IBIL were positively correlated with those of patients administered with antihypertensive drugs,and the increase of DBIL level was a risk factor for hypertensive patients left untreated(P<0.05).Conclusion:Elevated serum bilirubin level was observed in patients undergoing antihypertensive medication,and level increase is related to genders.
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基本信息:
中图分类号:R544.1
引用信息:
[1]朱丽君,张晓宇,方正美,等.皖北地区高血压患者胆红素水平与血压变化的相关研究[J].皖南医学院学报,2020,39(01):80-83.
基金信息:
国家自然科学基金项目(81874280);; 安徽省重点研究与开发计划(1804h08020261);; 安徽高校自然科学研究项目(KJ2019A0404,KJ2019A0405)
2020-02-15
2020-02-15